On this day:
The frozen bodies of Robert Scott and his men are found on the Ross Ice Shelf in Antarctica.
1927
Leon Trotsky is expelled from the Soviet Communist Party, leaving Joseph Stalin in undisputed control of the Soviet Union.
1948
In Tokyo, an international war crimes tribunal sentences seven Japanese military and government officials, including General Hideki Tojo, to death for their roles in World War II.
1969
Vietnam War: My Lai Massacre – Independent investigative journalist Seymour Hersh breaks the My Lai story.
1980
The NASA space probe Voyager I makes its closest approach to Saturn and takes the first images of its rings.
1981
Space Shuttle program: mission STS-2, utilizing the Space Shuttle Columbia, marks the first time a manned spacecraft is launched into space twice.
1997
Ramzi Yousef is found guilty of masterminding the 1993 World Trade Center bombing.
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"This fishing tackle manufacturer I knew had all these flashy green and purple lures. I asked, 'Do fish take these?' 'Charlie,' he said, 'I don't sell these lures to fish.'"--Berkshire Hathaway's Charles T. Munger, as quoted in FORTUNE
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The assumption that virtue is woven throughout each man to one degree or another is a classical idea: men are made, for better or worse, from a pure or less pure metal. Plato's men are of gold, silver and bronze. Events--and life--'test a man's mettle' (originally a different spelling of metal.). A man who is mostly honest will be mostly brave. A man who can not be trusted in business cannot be trusted in love. So we seek moral advice from people successful in unrelated fields. What does the popstar think of deficit spending? How does the linebacker view our diplomatic approach to Brazil? Strangely, the converse is unusual. Rarely do we ask, what does the math teacher think of Cover 2?
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Yakult Lady – one of tens of thousands across Japan who deliver the eponymous probiotic drinks directly to people's homes. On paper they're delivery workers, but in practice they're part of the country's informal social safety net. In a country grappling with a rapidly ageing population and a deepening loneliness crisis, Yakult Ladies have become an unlikely source of community, helping to reduce the problem of isolation one drop-off at a time.
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Eight people are dead, and 17 others are hurt, two critically, after part of a three-story building collapsed into a construction site at the corner of Flatbush and Bedford avenues in Flatbush, Brooklyn, just after 4 p.m. Wednesday, according to the FDNY.
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The Working Families Party, usually a vehicle for left-wing candidates to grow their vote, has pulled ahead of the Republican Party — with 34 endorsed candidates in the Senate and 65 in the Assembly, and will outnumber the GOP in both NY state chambers in January. Read that again.
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Agent Scott Boras continues to try to wag the baseball dog.
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Nuclear Power, Microbes, and Government Oversight
A recent article discussed the impact of outside influence on progress, both technical and scientific. The discussion starts with nuclear power, then settles on microbiology:
Construction costs for early U.S. demonstration reactors fell 81 percent between 1954 and 1968. For reactors begun between 1967 and 1972, costs rose 187 percent. The 1971 Calvert Cliffs decision and then the reaction to Three Mile Island in 1979 accelerated the cost increases and slowed construction even more.
What might have happened had the earlier learning and deployment trends continued? Peter Lang’s 2017 paper in Energies estimates that nuclear power would have cost about one-tenth as much by 2015. The additional generation could have avoided as many as 9.5 million premature deaths.
In the 1980s, officials decided to regulate engineered microbes under the Toxic Substances Control Act, a law written for industrial chemicals. Microbes swap genes all the time, but EPA treats them as “new” whenever DNA is introduced from another genus. As a result, even a marker gene used simply to identify successfully edited cells can trigger review if it remains in the organism. McCarty reports that researchers filed more than 240 applications between 1987 and 2018: “Only a few were ever approved for widespread use.
What have we lost? We can’t know for sure, but among the plausible losses McCarty discusses are engineered bacteria that detect buried explosives, microbes that extract rare-earth metals, and improved plastic-digesting enzymes. Similarly, Chernia et al. write:Promising many societal benefits, emergent products of biotechnology involve releasing genetically modified microbes (GMMs) into the environment. However, regulatory challenges limit their use. So far, GMMs have mainly been tested in agriculture and environmental cleanup, with few approved for commercial purposes. Current government regulations inadequately address modern genetic engineering and limit the potential of gut therapeutics, skin products, self-repairing materials, ocean pollution treatment, anti-corrosion coatings, etc.
And those are just some of the plausible first-stage losses. Perhaps even more importantly, we learn by doing. Thus, no doing, no learning. The first approved product is rarely the safest or the best but when we fail to approve the first we don’t get the much better 5th. Forty years of that process could have taken us well beyond the applications McCarty describes. We must build to build better.
Nuclear power at least left us enough reactors to get some idea of what we lost. With microbes, I needed McCarty to tell me there was something missing even though I study these issues for a living. And note one reason new microbe loss was invisible. No vote was ever taken. No debate was ever had. Officials in the 1980s reasoned that genomes are made of chemicals and chemicals are covered, and that doctrine has governed the field ever since despite being overly broad and excessively costly.
How many other gaps in our technology have explanations buried in the Federal Register?--from Tabarrok
And, unsaid, what would be gained by raiding these documents with AI?